Protein & Heart Disease

Protein #HeartDisease #Biolayne Get my new nutrition coaching app: Carbon Diet Coach for iOS and android to get custom nutrition coaching for less than …


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  2. I did my PhD in omega-3 fats and their cardioprotective benefits and I mostly agree with what he is saying. Before anyone gets confused in thinking that the benefits mentioned by Layne are because of the high protein content, I just want to highlight that the mediterranean diet (my definition = consisting of fatty fish) that are high in polyunsaturated fats (omega-3), not saturated fats (there is a significant difference), are protective against cardiovascular diseases mainly because of the vasodilation effects of omega-3 fats, which mostly include DHA and EPA. I have done multiple studies using rodent arteries and I can tell you that the vasodilation effects are very potent so please take your omega-3s especially if you have underlying cardiovascular disorders. You can read my paper below:

    Also a better experimental design for the above debate ideally would be to asess different conentration ranges of protein content in the diet without changing other variables such as carbohydrate, fats, micronutrient, etc. These studies are usually flawed since they always forget to keep the other variables constant (same) for each group and as a result you can always argue that these uncontrolled variable (for eg: fats) might be the ones involved and therefore eliciting the effect.

  3. Perhaps there is some evidence that contradicts your position.: A study from researchers at the University of Eastern Finland found that men who consumed a high-protein diet increased their risk of developing heart failure by 33 percent. . They found that the men who ate the most protein from animal sources had a 43 percent greater risk of heart failure compared with those who ate the least amount of protein.Those that consumed a high amount of protein from dairy sources had a 49 percent increased risk. Those who consumed most of their protein from plants had a 17 percent increased risk.


    Also see my two postings below.

  4. High protein diets, where the primary source of protein is fron animal products may have a connection to heart disease. I underscore the word "may.." . See

  5. Hello Biolayne. You're the only source that I have seen label the as a high protein diet. Since the Mediterranean diet is high in plant based materials, the diet tends to be lower in protein. (According to the Mayo Clinic and many other sources, the diet is based around plant based foods with only limited amounts of animal products).

  6. Good of you to break this down, i first picked this up on documentary on the "blue zone" in Italy. It's an area where people tend to life well into their 90's and the non-definitive conclusion they gave you at the end was that a high protein diet could indeed increase your chance of illnesses far more than a high calorie diet. A whole bunch of anecdotal evidence was used obviously and loaded with emotions, so i didn't buy it completely but it was something that i kept thinking about from time to time. So Thank you!

  7. Hi Layne,

    Awesome video! Really enjoyed the video and learning that high protein diets don't contribute to heart disease as people like to think it does.

    Big thank you for making the video.



  8. Keep saturated fats low (Oh the American Heart Association was so wrong all the time.) And keep your protein intake reasonable at say 30 percent of your daily caloric intake. Or 0.8-1 g/lb body weight assuming bodyfat levels are within a decent range. Which is in line with the amount of protein needed to stimulate protein synthesis every 3-5 hours with around 3.2 grammes of L-Leucine which yield roughly 30-40 grammes of protein each.

  9. Layne is the best in the business and I love when he snaps on the Keto geeks. I bet if they were in his face he would snap them like twigs.

  10. Question from an exercise physiologist with little expertise on this area. Doesn't the same mechanism of action explained in this video occur during endurance training? We do observe hypertrophy of the left ventricle and higher mTOR activity following HIIT (4*4 intervals for example). Is this a less beneficial sort of hypertrophy of the heart walls? And how can we infer that this observed hypertrophic activity in this study is detrimental?

  11. kinda funy in a way how "high protein" diet is bad for the heart, meanwhile the heart is pure musle xD

  12. Non-scientist here, but wouldnโ€™t the study give us more information about protein if the ratio of calories from fat to calories from carbs stayed consistent between the groups, rather than also making the high protein diet be low in carbohydrates?

  13. Great video!
    But i have also read multiple studies about protein and longevity of our life span, especially bcaa group, that seems to reduce it. Can you comment that?

  14. David Sinclair in JRE #1234 stated that he is afraid of high protein diets because of some weak evidence that it may cause problems (he was really vague and unsure as well). His believes may be stated on this study. Thanks for clearing things out, Layne! :)

  15. Wow yeah this is some deep stuff. Layne it would be awesome with these types of videos to have some visuals to help digest the content of the study. It's really good detail but sometimes I'm not catching everything. It is interesting to see how they approached this but I agree with you in the analysis that you gave. Makes a lot of sense. Thanks for bringing this out to the audience and shining some light in it!

  16. The med diet is mainly fish though for protein, i'd like to see if that makes a difference. I lived in ibiza before and they ate alot of sea food mixes, paella..the locals seem to like squid a lot, sardines in terms of protein. Tsimane people have the healthiest arteries on the planet though and there diet is mainly carb based.

  17. 1:00 preach! I have a biochemistry degree, and I've made this mistake many times before when forming hypotheses. I've hypothesized that low CHO diets were better for fat loss than high CHO diets b/c a lower CHO intake would lead to less lipogenesis, and that would be the difference maker. Welp, data showed that my hypothesis was wrong.

    Big picture > mechanisms. Data > hypotheses.

  18. 'This is a concert'

    That was the moment I liked the video. What a beautiful way of describing what you have been telling us all along Layne! Keep up the good work! I love the content ;)

  19. Thank you for your content. What about protein and renal disease? Specially if there is proteinuria.

  20. The Mediterranean diet in real life is not high protein, I live in Spain, I can tell you, The huge vast majority of people eat a shit amount of protein

  21. you should Layne, hop on the channel of Leo and Longevity. Do a vid together.

  22. I just canโ€™t wait for Tom Delauer et al to get a hold of this study and make a video on it. Heโ€™s going to be talking about MTor for days!

  23. Hey, I'm a postdoc (biochemistry) studying proteins in heart disease, so this title really jumped out to me haha! I don't study metabolism though (I study cardiac myosin mutations in hypertrophic cardiomyopathies). I really enjoy your content man! You have a good way of distilling complex topics for a more general audience without diluting the content.

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